Vitamin D deficiency is a global health concern, especially during rapid growth in infancy, childhood, and adolescence.To evaluate the role of Vitamin – D supplementation and monitor as well as compare serum 25-OH-Vit-D levels, the major marker of Vitamin-D status,in children taking anti-seizure medications (ASMs) a hospital based, Randomized Control Trial (An Experimental Study) was conducted in Paediatric and Biochemistry Department of Government Medical College and Rajindra Hospital,Patiala over a period of one year(February,2023 to February,2024) on 80 Children between age group 1-18 yrs of age with newly diagnosed seizure disorder receiving sodium valproate or carbamazepine monotherapy after following the inclusion and exclusion criteria. The patients were subdivided into study group of 40 who were supplemented with Vitamin D and a control group comprising of 40 who were not given Vitamin D supplementation. They were subjected to evaluation of Vitamin D levels at baseline and after a follow up duration of 3 months.

Results indicated that the mean Vitamin-D levels at baseline in control group and study group were 39.16 ±8.44 and 39.35 ±9.46 respectively which after follow up duration were decreased to 36.28 ±8.69 in control group whereas in study group with Vitamin-D supplementation was given the levels increased to 41.34±9.19. On analysis it showed a significant difference in both the groups with p value of 0.017. We also compared effects of Carbamazepine(CBZ) versus Valproate(VPA) on Vitamin-D levels. On analysis it represented that decrease in Vitamin-D levels was greater in CBZ group i.e. -3.43±2.79 versus -2.35±3.29 in VPA group respectively,but the difference was not significant (p=0.306).

It concluded that regular monitoring of Vitamin-D levels should be done on follow up of patient taking anti-seizure medication,even in children with normal growth and development,no limitation of physical activity and adequate exposure to sunlight. Role of Vitamin-D supplementation in maintenance dose of 600 I.U was also established when prescribing anticonvulsants to prevent insufficiency/deficiency.